PP1A, Active (P13-20GH)
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Description :Recombinant full-length human PP1A was expressed in E.coli cells using the N-terminal GST, His tags.
Species :Human
Tag :GST/His tags
Expression System:E.coli
Sequence :Full Length
Genbank Number :NM_002708
Specific Activity :Sample Enzyme Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Phosphatase Assay, Western Blot
Molecular Weight :64 kDa
Gene Aliases :PP-1A, PPP1A, PPP1CA, MGC1674, MGC15877
Scientific Background :PP1A is a serine/threonine specific protein phosphatase family which is involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. PP1A is one of the three catalytic subunits of protein phosphatase 1 (PP1) (1). PP1A functions as a suppressor of learning and memory and as a potential mediator of cognitive decline during aging (2).PP1A is also play a main role in splice site selection and is an important regulator of cardiac function.
References :
1. Cohen, P.et.al: Protein phosphatases come of age. J. Biol. Chem. 264: 21435-21438, 1989.
2. Genoux, D. et.al: Protein phosphatase 1 is a molecular constraint on learning and memory. Nature 418: 970-975, 2002.
Product Sheets (By Lot #) :
Research Areas :Cancer, Cardiovascular Disease, Cell Cycle, ERK/MAPK Pathway, Metabolic Disorder, Phosphatases, Ser/Thr Kinases