Gamma-synuclein Protein (S22-30CH)
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Description :Recombinant full length human Gamma-synuclein was expressed in E. coli cells using an N-terminal His tag.
Species :Human
Tag :HIS tag
Expression System:E.coli
Sequence :Full Length
Genbank Number :NM_003087
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Western Blot
Molecular Weight :~17.5 kDa
Gene Aliases :BCSG1, PERSYN, PRSN, SR
Scientific Background :Gamma-synuclein or synuclein, gamma (breast cancer-specific protein 1) is a member of the synuclein family of proteins which are believed to be involved in the pathogenesis of neurodegenerative diseases. Gamma-synuclein gene may also be overexpressed in ovarian cancers (1). The overexpression of Gamma-synuclein may indicate breast cancer malignant progression from benign or in situ carcinoma. Gamma-synuclein may also play a role in motor neurons dysfunction and cell death (2). Synuclein proteins play an important role in regulating neurotransmitter release from specific populations of midbrain dopamine neurons through mechanisms that differ from those reported in other neurons.
References :
1. Ji, H. et.al: Identification of a breast cancer-specific gene, BCSG1, by direct differential cDNA sequencing. Cancer Res. 57: 759-764, 1997.
2. Lavedan, C. et.al: Absence of mutation in the beta- and gamma-synuclein genes in familial autosomal dominant Parkinson's disease. DNA Research 5: 401-402, 1998.
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Research Areas :Cancer, Neurobiology, Cancer, Neurobiology