Beta-synuclein Protein (S22-30BH)
FOR BULK ORDER REQUESTS PLEASE CONTACT US
Description :Recombinant full length human Beta-synuclein was expressed in E. coli cells using an N-terminal His tag.
Species :Human
Tag :HIS tag
Expression System:E.coli
Sequence :Full Length
Genbank Number :NM_003085
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Western Blot
Molecular Weight :~19 kDa
Gene Aliases :(None)
Scientific Background :Beta-synuclein is a member of the synuclein family of proteins which are believed to be involved in the pathogenesis of neurodegenerative diseases. Beta-synuclein is highly homologous to alpha-synuclein which is abundantly expressed in the brain and putatively inhibits phospholipase D2 selectively. Beta-synuclein may play a role in neuronal plasticity, is abundant in neurofibrillary lesions of patients with Alzheimer disease. Beta-synuclein is shown to be highly expressed in the substantia nigra of the brain, a region of neuronal degeneration in patients with Parkinson disease but no direct relation to Parkinson disease has been established (1). An alteration in Beta-synuclein may impair its normal inhibitory action on the formation of toxic alpha-synuclein fibrils, thereby indirectly contributing to disease pathogenesis (2).
References :
1. Ohtake, H. et.al: Beta-synuclein gene alterations in dementia with Lewy bodies. Neurology 63: 805-811, 2004.
2. Lavedan, C. et.al: Absence of mutation in the beta- and gamma-synuclein genes in familial autosomal dominant Parkinson's disease. DNA Res. 5: 401-402, 1998.
Product Sheets (By Lot #) :
Research Areas :Cancer, Neurobiology, Cancer, Neurobiology