MLL5 (KMT2E), Active(M345-381G)
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Description :Recombinant human MLL5 (1-548) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :1-548
Genbank Number :NM_182931
Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Methyltransferase Assay
Molecular Weight :100 kDa
Gene Aliases :HDCMC04P; MLL5; NKp44L
Scientific Background :Mixed-lineage leukemia protein 5 (MLL5) plays a key regulatory role in hematopoiesis by mediating mono- or demethylation of lysine-4 of histone H3 (1). MLL5 can associate with host cell factor-1 (HCF-1) and be recruited to E2F1-responsive promoters, and thus promotes cell cycle progression (2). Isoform NKp44L acts as cellular ligand for a natural cytotoxicity receptor, which is critical for NK cell-mediated innate immunity (3).
References :
1. Emerling, B.M., et al. MLL5, a homolog of Drosophila trithorax located within a segment of chromosome band 7q22 implicated in myeloid leukemia. Oncogene. 21(31):4849-54, 2002.
2. Zhou, P., et al. Mixed lineage leukemia 5 (MLL5) protein regulates cell cycle progression and E2F1-responsive gene expression via association with host cell factor-1 (HCF-1). J Biol Chem. 288(24):17532-43, 2013.
3. Baychelier, F., et al. Identification of a cellular ligand for the natural cytotoxicity receptor NKp44. Blood. 122(17):2935-42, 2013.
Product Sheets (By Lot #) :
Research Areas :Cancer