LOXL4 Protein (L264-31G)
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Description : Recombinant human LOXL4 (492-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species : Human
Tag : GST tag
Expression System : Sf9 insect cells using baculovirus
Sequence : 492-end
Genbank Number : BC013153
Purity : Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications : Enzyme Assay, Western Blot
Molecular Weight : 56 kDa
Gene Aliases : LOXC, FLJ21889
Scientific Background : LOXL4 or lysyl oxidase-like 4 is a member of the lysyl oxidase family of amine oxidases. LOXL4 catalyzes the final enzymatic step required for the lysine-derived crosslinks essential for the formation of collagen fibrils and insoluble elastic fibers within the extracellular matrix (1). LOXL4 can also contribute to developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis. LOXL4 is highly expressed in skeletal muscle, testis, and pancreas (2).
References :
1. Asuncion, L.et.al: A novel human lysyl oxidase-like gene (LOXL4) on chromosome 10q24 has an altered scavenger receptor cysteine rich domain. Matrix Biol. 20: 487-491, 2001.
2. Maki, J. M. et.al: Cloning and characterization of a fifth human lysyl oxidase isoenzyme: the third member of the lysyl oxidase-related subfamily with four scavenger receptor cysteine-rich domains. Matrix Biol. 20: 493-496, 2001.
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Research Areas : Cancer, Metabolic Disorder,