DGKK, Active (D28-10G)
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Description: Recombinant full-length human DGKK was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species : Human
Tag : N Terminal GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :Full length
Genbank Number :NP_001013764.1
Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications: Kinase Assay
Molecular Weight: 171 kDa
Gene Aliases: Diacylglycerol kinase kappa; DGK-kappa
Scientific Background: Diacylglycerol kinase kappa (DGKK) is a member of the type II diacylglycerol kinase subfamily. Diacylglycerol kinases modulate the concentration of intracellular diacylglycerol by phosphorylating, producing phosphatidic acid (PA) (1). PA regulates signaling proteins, such as protein kinases and phosphatases, and can induce cell mitosis through regulation of growth factors (2). Genetic variants of DGKk are associated with hypospadias in mild and moderate Han Chinese cases (3).
References :
1. Imai, S. et al: Identification and characterization of a novel human type II diacylglycerol kinase, DGK kappa. J Biol Chem. 2005; 280(48):39870-81.
2. Buckland, A.G. et al: Anionic phospholipids, interfacial binding and the regulation of cell functions. Biochim Biophys Acta. 2000; 1483(2):199-216.
3. Xie, H. et al: Association between diacylglycerol kinase kappa variants and hypospadias susceptibility in a Han Chinese population. Asian journal of andrology. 2018; 20 (1): 85-89.
Product Sheets (By Lot #) :
Research Areas :Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Cell Cycle, Inflammation, PKA/PKC Pathway