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Description :Recombinant full-length human CDK11/CyclinC was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Tag :GST tags
Expression System:Sf9 insect cells using baculovirus
Sequence :Full length
Genbank Number :NM_015076
Genbank Number 2 :NM_005190
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Enzyme Assay, Western Blot
Molecular Weight :CDK11 ~92 kDa, and Cyclin H1 ~55 kDa
Gene Aliases :CDK11: CDC2L6; CDK8-like; bA346C16.3; KIAA1028
CyclinC: CCNC, CycC
Scientific Background :CDK11/Cyclin C is a member of the p34Cdc2 protein kinase family which are known to be essential for eukaryotic cell cycle control. CDK11/Cyclin C gene complex may harbor 1 or more tumor suppressor genes affected by chromosome 1p36 modifications in neuroblastoma (1). CDK11/Cyclin C expression is regulated during murine embryogenesis and its activity is coordinately regulated with that of p34 (cdc2) during the cell cycle (2).
1. Lahti, J. M.. et.al: Alterations in the PITSLRE protein kinase gene complex on chromosome 1p36 in childhood neuroblastoma. Nature Genet. 7: 370-375, 1994.
2. Bunnell, B.et.al: Elevated expression of a p58 protein kinase leads to changes in the CHO cell cycle. Proc. Nat. Acad. Sci. 87: 7467-7471, 1990. Note: Erratum: Proc. Nat. Acad. Sci. 88: 2612 only, 1991.
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Research Areas :Cancer, Cell Cycle, Ser/Thr Kinases