AURORA B (D200A) Protein (A31-12G)
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Description: Recombinant full-length human AURORA B (D200A) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species: Human
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence : Full Length
Genbank Number :NM_004217
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Western Blot
Molecular Weight :~65 kDa
Gene Aliases :AURKB, AIK2; AIM1; ARK2; AurB; IPL1; AIM-1; STK12
Scientific Background: AURORA B is a member of the Aurora kinase family that associates with microtubules during chromosome movement and segregation. AURORA B localizes to the microtubules near kinetochores, specifically to the specialized microtubules called K-fibers (1). AURORA B inhibits the microtubule depolymerizing activity of mitotic centromere-associated kinesin (MCAK) by phosphorylating MCAK on Ser92 (2). This phosphorylation also regulates MCAK translocalization from kinetochores to the centromere. AURORA B has been identified as a target for the development of new anticancer agents since inhibition of AURORA B gives rise to the more pronounced anti-proliferative phenotype.
References :
1. Shannon, K B. et al: Chromosome dynamics: new light on Aurora B kinase function. Curr Biol. 2002 Jul 9;12(13):R458-60.
2. Andrews, P. D. et al: Aurora B regulates MCAK at the mitotic centromere. Dev. Cell 6: 253-268, 2004.
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Research Areas :Apoptosis/Autophagy, Cancer, Cytoplasmic Tyrosine Kinases, Cancer, Apoptosis/Autophagy, Cytoplasmic Tyrosine Kinases