FLT3-ITD-NPOS, Active(F12-12DG)
FOR BULK ORDER REQUESTS PLEASE CONTACT US
Description :Recombinant human FLT3-ITD-NPOS (571-993) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :571-993 (FLT3-ITD-NPOS)
Genbank Number :NM_004119
Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Kinase Assay
Molecular Weight :82 kDa
Gene Aliases :FLT3-ITD, FLT3 (L610_E611insCSSDNEYFYVDFREYEYDLKWEF-PRENL), FLK2, STK1, CD135
Scientific Background :Fms-related tyrosine kinase 3 (FLT3) is a gene that encodes for a tyrosine kinase that activates pathways in hematopoietic cells important in cellular proliferation. FLT3 is frequently mutated in acute myeloid leukemia (AML), myelodysplastic syndromes, other hematologic malignancies, and colorectal cancer. FLT3 mutations are observed in 24.3% of AML, of which internal tandem duplications (ITD) are the most frequent. FLT3 ITD occurs when sequences of less than ten to several hundred bases in length are repeated within the juxtamembrane domain are always “in-frame”.
References :
1. http://www.mycancergenome.org/content/disease/acute-myeloid-leukemia/flt3/277/
2. Fathi AT, et al: Treatment of FLT3-ITD acute myeloid leukemia. Am J Blood Res. 1(2):175-89, 2011
Product Sheets (By Lot #) :
Research Areas :AKT/PKB Pathway, Angiogenesis, Cancer, ERK/MAPK Pathway, Receptor Tyrosine Kinases