BTK (C481F), Active (B10-12FH)
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Description :Recombinant full-length human BTK (C481F) was expressed by baculovirus in Sf9 insect cells using an N-terminal His tag.
Species :Human
Tag :His tag
Expression System:Sf9 insect cells using baculovirus
Sequence :Full Length (C481F)
Genbank Number :NM_000061
Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Kinase Assay
Molecular Weight :~75kDa
Gene Aliases :AT; ATK; BPK; XLA; IMD1; AGMX1; PSCTK
Scientific Background :BTK (also known as Bruton tyrosine kinase) plays a crucial role in B-lymphocyte differentiation and activation. BTK interacts with SRC homology 3 domains of FYN, LYN and HCK that are activated upon stimulation of B- and T-cell receptors (1).Defects in the BTK gene cause Agammaglobulinemia, an X-linked immunodeficiency characterized by failure to produce mature B lymphocyte cells and associated with a failure of Ig heavy chain rearrangement. The unique role of BTK makes it a desirable target for potential anti-cancer, anti-inflammatory and anti-viral agents as well as other treatments (2).
References :
1. Cheng, G. et al: Binding of Bruton's tyrosine kinase to Fyn, Lyn, or Hck through a Src homology 3 domain-mediated interaction. Proc. Nat. Acad. Sci. 91: 8152-8155, 1994.
2. Vassilev, A O. et al: Therapeutic potential of inhibiting Bruton's tyrosine kinase, (BTK).Curr Pharm Des. 2004;10(15):1757-66.
Product Sheets (By Lot #) :
Research Areas :Cancer, Cytoplasmic Tyrosine Kinases, Inflammation, NfkB Pathway, Cancer, Inflammation, NfkB Pathway, Cytoplasmic Tyrosine Kinases