KDM1B Protein(K421-30BG)
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Description :Recombinant full-length mouse KDM1B was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species :Mouse
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :Full length
Genbank Number :NM_172262
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Western Blot
Molecular Weight :~118 kDa
Gene Aliases :4632428N09Rik; AI482520; Aof1
Scientific Background :KDM1B encodes Lysine-specific histone demethylase 1B that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. It specifically associates with the coding region of its target genes. Removal of endogenous KDM1B promotes an increase in H3K4me2 levels and concurrent decrease in H3K9me2 levels, with a consequent down-regulation of targeted gene transcription.
References :
1. Fang R, et al. Human LSD2/KDM1b/AOF1regulates gene transcription by modulating intragenic H3K4me2 methyla-tion. Mol Cell. 2010 Jul 30;39(2):222-33.
2. http://www.uniprot.org/uniprot/Q8NB78.
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Research Areas :Cancer, Cell Cycle, Inflammation