2019-nCoV Spike protein S1 (T19R, ∆157-158, L452R, T478K, D614G, P681R)  (C19S1-G231FH)

2019-nCoV Spike protein S1 (T19R, ∆157-158, L452R, T478K, D614G, P681R) (C19S1-G231FH)

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Description: Recombinant 2019-nCoV Spike protein S1 (T19R, ∆157-158, L452R, T478K, D614G, P681R) (16-685) was expressed in CHO cells using a C-terminal His- tag. 

Species: SARS-CoV-2

Tag: HIS tag

Expression System: CHO Cells

Sequence: 16-685

Genbank Number: MN908947

Purity: Sample Purity Data. For specific information on a given lot, see the related technical datasheet.

Storage, Stability, and Shipping: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Molecular Weight:  76 kDa

Gene Aliases : 2019-nCoV s1, SARS-CoV-2 spike S1, SARS-CoV-2 S1, novel coronavirus spike s1, nCoV spike s1, coronavirus spike S1, Delta variant

Scientific Background: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) remains the most rapidly spreading disease since 2020. The spike glycoprotein (S) of coronavirus, a type I transmembrane protein containing two subunits S1 and S2, facilitates viral genome entry into the host cells through the interaction with angiotensin-converting enzyme 2 (ACE2) (1). B.1.617, also referred to as the Indian variant, caused a surge in COVID-19 cases in India in early 2021. This variant has also been reported in UK and US. B.1.617 has 13 mutations that result in amino acid changes. These mutations include T19R, ∆157-158, L452R, T478K, D614G, P681R. As new variants displace the first-wave virus, it is pivotal to evaluate their transmissibility, virulence and their possible tendency to escape antibody neutralization (2, 3).

References : 

  1. 1. Lan J, et al: Crystal structure of the 2019-nCov spike receptor-binding domain bound with the ACE2 receptor. Nature. 2020, 581:215-220.
    2. Peacock S: Expert reaction to cases of variant B.1.617 (the ‘Indian variant’) being investigated in the UK. Science Media center. 2021.
    3. "Lineage B.1.617". PANGO lineages. Retrieved 12 June 2021.

Product Sheets (By Lot #) :

J3908-18