UBE2L3 (UBCH7) Protein(U228-30H)
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Description :Recombinant full-length human UBE2L3 was expressed in E. coli cells using an N-terminal His tag.
Species :Human
Tag :His tag
Expression System:E.coli
Sequence :Full length
Genbank Number :NM_003347
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Western Blot
Molecular Weight :18 kDa
Gene Aliases :E2-F1; L-UBC; UBCH7; UbcM4
Scientific Background :Ubiquitin-conjugating enzyme E2 L3 (UBE2L3) belongs to the ubiquitin-conjugating enzyme family of the ubiquitin-proteasome pathway, facilitating the transfer of activated ubiquitin from ubiquitin-activating enzyme to target proteins with the help of ubiquitin-protein ligases. It specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases and does not function with most RING-containing E3 ubiquitin-protein ligases. Catalyzes 'Lys-11'-linked polyubiquitination in vitro.
References :
1. Nuber U, et al: Cloning of human ubiquitin-conjugating enzymes UbcH6 and UbcH7 (E2-F1) and characterization of their interaction with E6-AP and RSP5. J Biol Chem. 1996 271:27105-800
2. David Y, et al: The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines. J Biol Chem. 2010 19;285:85105-604.
3. http://www.uniprot.org/uniprot/P68036
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Research Areas :Cell Cycle, Neurobiology