UBE2H Protein(U223-30H)
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Description :Recombinant full length human UBE2H was expressed in E. coli cells using an N-terminal His tag.
Species :Human
Tag :HIS tag
Expression System:E.coli
Sequence :Full Length
Genbank Number :NM_003344
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Western Blot
Molecular Weight :~21 kDa
Gene Aliases :E2-20K; UBC8; UBCH; UBCH2
Scientific Background :UBE2H or ubiquitin-conjugating enzyme E2H is a member of the E2 ubiquitin-conjugating enzyme family which is located on chromosome 7 (1). UBE2H is known to act on histones and cytoskeletal proteins, both involved in the degenerative pathway of the motor neuron. UBE2H expression is increased during erythroid differentiation of hCD34(+) cells. Tal1 transcription factor, which is essential for the development of the hematopoietic system and plays a role during definitive erythropoiesis in the adult, activates UBE2H expression, whereas Tal1 knock-down reduced UBE2H expression and ubiquitin transfer activity (2).
References :
1. Kaiser, P. et.al: Human ubiquitin-conjugating enzyme homologous to yeast UBC8. J. Biol. Chem. 269: 8797-8802, 1994.
2. Lausen J,Targets of the Tal1 transcription factor in erythrocytes: E2 ubiquitin conjugase regulation by Tal1. J Biol Chem. 2010 Feb 19;285(8):5338-46.
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Research Areas :Neurobiology, Cell Cycle, Cancer